Catalog No: ARP72515_P050
Price: $0.00
SKU
ARP72515_P050
Availability: Domestic: within 1-2 days delivery | International: 1-2 days
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Datasheets/ManualsPrintable datasheet for anti-CASP8 (ARP72515_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C-terminal region of Human CASP8
PurificationAffinity Purified
Peptide SequenceSynthetic peptide located within the following region: LCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKL
Concentration0.5 mg/ml
Blocking PeptideFor anti-CASP8 (ARP72515_P050) antibody is Catalog # AAP72515
Gene SymbolCASP8
Alias SymbolsCAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8
NCBI Gene Id841
Description of TargetThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Uniprot IDQ14790-3
Protein Size (# AA)395
Molecular Weight43kDa
Protein InteractionsBAX; ced-4; FADD; UBC; ERLIN2; PRDX6; TNF; CRYAB; XIAP; TNFSF10; RIPK1; HECTD3; SQSTM1; GZMB; PLA2G4B; RB1; PLIN4; BCAP31; PDIA6; CFLAR; SNRPD3; PRKCI; BIRC2; RIPK3; TNFRSF10A; TNFRSF10B; CUL3; TRAF2; CASP10; PARK7; LRRK2; CARD11; FIS1; CASP3; FASLG; TOPO
  1. What is the species homology for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "CASP8 Antibody - C-terminal region (ARP72515_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    This target may also be called "CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8" in publications.

  5. What is the shipping cost for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "43kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "CASP8 Antibody - C-terminal region (ARP72515_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "CASP8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "CASP8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "CASP8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "CASP8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "CASP8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "CASP8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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