CASP6 Antibody (OAPB00291)

Catalog No: OAPB00291 (Formerly GWB-123E37)

Size:100UG

Western blot analysis of caspase-6 in Jurkat cell lysate with caspase-6 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.

Immunocytochemistry of caspase-6 in Jurkat cells with caspase-6 antibody at 2 ug/mL.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. Caspase-6 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: Caspase-6 antibody can be stored at 4C for three months and-20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: Caspase-6 antibody was raised against a 15 amino acid synthetic peptide from near the amino-terminus of human Caspase-6. The immunogen is located within the first 50 amino acids of Caspase-6.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-CASP6 (OAPB00291) antibody is Catalog # OEPB02384
• Specificity: Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
• Application Info: Caspase-6 antibody can be used for the detection of caspase-6 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 2 ug/mL. Optimal dilutions for each application to be determined by the researcher.
• Other Applications Image 1 Data: Immunocytochemistry of caspase-6 in Jurkat cells with caspase-6 antibody at 2 ug/mL.
• Reference: Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.;
  Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.;
  Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.;
  Fernandes-Alnemri T, Litwack G, and Alnemri ES. Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res. 1995; 55:2737-42.

Target Info

• Gene Symbol: CASP6
• Gene Full Name: caspase 6
• Alias Symbols: apoptotic protease MCH-2;caspase 6, apoptosis-related cysteine peptidase;caspase 6, apoptosis-related cysteine protease;caspase-6;MCH2.
• NCBI Gene Id: 839
• Protein Name: Caspase-6|caspase-6 isoform alpha precursor [Homo sapiens]
• Description of Target: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
• Uniprot ID: P55212
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001217
• Nucleotide Accession #: NM_001226.3; NM_032992.2