CASP4 Recombinant Protein (OPCD01894)

Catalog No: OPCD01894

CASP4 Recombinant Protein (OPCD01894) using SDS-PAGE

CASP4 Recombinant Protein (OPCD01894) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Bos taurus|Bovine
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys81-Asp270
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: CASP4
• Gene Full Name: caspase 4, apoptosis-related cysteine peptidase
• Alias Symbols: CASP13;CASP-13;CASP-4;caspase 4, apoptosis-related cysteine protease;caspase-13;caspase-4;ERICE;evolutionary related interleukin-1-beta-converting enzyme.
• NCBI Gene Id: 338039
• Protein Name: Caspase-4
• Description of Target: Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion. Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity. Involved in cell death induced by endoplasmic reticulum stress. Activated by direct binding to LPS without the need of an upstream sensor. Does not directly process IL1B. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (By similarity).
• Uniprot ID: Q5E9C1
• Protein Accession #: NP_788811.1
• Nucleotide Accession #: NM_176638.5
• Protein Size (# AA): Lys81~Asp270
• Molecular Weight: 35kDa