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Datasheets/Manuals | Printable datasheet for anti-CARD14 (OASG00986) antibody |
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Predicted Species Reactivity | Human, Mouse |
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Product Format | Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Application | IHC-P, IF |
:: | Cellular Localization: Isoform 1: Cytoplasm ; Isoform 2: Cytoplasm ; Isoform 3: Cytoplasm Tissue Specificity: Isoform 1 is detected in placenta and epidermal keratinocytes . Isoform 2 is detected in leukocytes and fetal brain. Sequence & Domain Family: A linker region between the coiled-coil and PDZ region holds the protein in an inactive state. |
Reconstitution and Storage | Store at -20C. Avoid repeated freeze/thaw cycles. |
Immunogen | Synthesized peptide derived from the Internal region of human CARD 14. Location: 260-340aa (Internal) |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration | 1 mg/ml |
Specificity | CARD 14 Polyclonal Antibody detects endogenous levels of CARD 14 protein. |
Application Info | IHC-P: 1:100~300 IF: 1:200~1000 ELISA: 1:40000 |
Gene Symbol | CARD14 |
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Gene Full Name | caspase recruitment domain family, member 14 |
Alias Symbols | PRP, PSS1, BIMP2, CARMA2, PSORS2 |
NCBI Gene Id | 79092; 170720; |
Description of Target | Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases . May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. ; Isoform 3: Not able to activate the inflammatory transcription factor NF-kappa-B and may fuction as a dominant negative regulator. |
Uniprot ID | Q9BXL6, Q99KF0 |
Molecular Weight | 110 kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "CARD14 Antibody - middle region (OASG00986)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".
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How long will it take to receive "CARD14 Antibody - middle region (OASG00986)"?
This item is available "Domestic: within 2-3 weeks delivery | International: 2-3 weeks".
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What buffer format is "CARD14 Antibody - middle region (OASG00986)" provided in?
This item is provided in "Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "CARD14 Antibody - middle region (OASG00986)"?
This target may also be called "PRP, PSS1, BIMP2, CARMA2, PSORS2" in publications.
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What is the shipping cost for "CARD14 Antibody - middle region (OASG00986)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "CARD14 Antibody - middle region (OASG00986)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "CARD14 Antibody - middle region (OASG00986)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "110 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "CARD14 Antibody - middle region (OASG00986)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "CARD14"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "CARD14"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "CARD14"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "CARD14"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "CARD14"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "CARD14"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.