CAPN10 Antibody - N-terminal region : HRP (ARP52404_P050-HRP)

Catalog No: ARP52404_P050-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAPN10
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 92%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%
• Peptide Sequence: Synthetic peptide located within the following region: MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEIC
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CAPN10 (ARP52404_P050-HRP) antibody is Catalog # AAP52404 (Previous Catalog # AAPP14348)

Target Info

• Reference: Kifagi,C., (2008) Diabetes Metab. 34 (3), 273-278
• Gene Symbol: CAPN10
• Gene Full Name: Calpain 10
• Alias Symbols: CANP10, NIDDM1
• NCBI Gene Id: 11132
• Protein Name: Calpain-10
• Description of Target: CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
• Uniprot ID: Q9HC96
• Protein Accession #: NP_075573
• Nucleotide Accession #: NM_023085
• Protein Size (# AA): 517
• Molecular Weight: 58kDa
• Protein Interactions: EFNB1; FLOT1; PSMA7; FANCC;