CAMK2B Antibody (OAAF02415)

Catalog No: OAAF02415 (Formerly GWB-ASD648)

Size:100 ug

Western blot analysis of extracts from COLO205/Jurkat cells, using CaMK2 beta/gamma Antibody. The lane on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: CaMK2β/γ antibody detects endogenous levels of total CaMK2β/γ protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; ELISA: 1:20000
• Reference: Deloukas P., Nature 429:375-381(2004).
  Breen M.A., Biochem. Biophys. Res. Commun. 236:473-478(1997).
  Tombes R.M., Biochim. Biophys. Acta 1355:281-292(1997).

Target Info

• Gene Symbol: CAMK2B|CAMK2G
• Gene Full Name: calcium/calmodulin dependent protein kinase II beta|calcium/calmodulin dependent protein kinase II gamma
• Alias Symbols: calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma;calcium/calmodulin-dependent protein kinase type II subunit beta;calcium/calmodulin-dependent protein kinase type II subunit gamma;CaM kinase II beta subunit;CAM2;CAMK;CAMK2;CAMKB;CAMKG;CAMK-II;caMK-II subunit beta;caMK-II subunit gamma;CaMKIIbeta;CaM-kinase II beta chain;MRD54;MRD59;proline rich calmodulin-dependent protein kinase.
• NCBI Gene Id: 816|818
• Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit beta|Calcium/calmodulin-dependent protein kinase type II subunit gamma
• Description of Target: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.|Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
• Uniprot ID: Q13554|Q13555
• Protein Accession #: NP_001211.3
• Molecular Weight: 62 kDa