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Catalog No: OPPA02268 (Formerly GWB-BSP417)
Size:5UG
Price: $75.00
SKU
OPPA02268
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CALR Protein (OPPA02268)

Datasheets/ManualsPrintable datasheet for OPPA02268
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid 20mM Tris-HCl (pH 8), 1mM DTT, 0.1M NaCl and 10% glycerol
HostE. Coli
Reconstitution and StorageStore at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.
PurificationPurified by standard chromatography
Concentration1 mg/ml
PurityGreater than 85% as determined by SDS-PAGE.
Peptide SequenceMGSSHHHHHH SSGLVPRGSH MEPAVYFKEQ FLDGDGWTSR WIESKHKSDF GKFVLSSGKF YGDEEKDKGL QTSQDARFYA LSASFEPFSN KGQTLVVQFT VKHEQNIDCG GGYVKLFPNS LDQTDMHGDS EYNIMFGPDI CGPGTKKVHV IFNYKGKNVL INKDIRCKDD EFTHLYTLIV RPDNTYEVKI DNSQVESGSL EDDWDFLPPK KIKDPDASKP EDWDERAKID DPTDSKPEDW DKPEHIPDPD AKKPEDWDEE MDGEWEPPVI QNPEYKGEWK PRQIDNPDYK GTWIHPEIDN PEYSPDPSIY AYDNFGVLGL DLWQVKSGTI FDNFLITNDE AYAEEFGNET WGVTKAAEKQ MKDKQDEEQR LKEEEEDKKR KEEEEAEDKE DDEDKDEDEE DEEDKEEDEE EDVPGQAKDE L.
TagN-terminal His Tag
Gene SymbolCALR
Alias SymbolsRO, CRT, SSA, cC1qR, HEL-S-99n
NCBI Gene Id811
Protein NameCalreticulin
Description of TargetCALR is a multifunctional protein that acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin is localized in the nucleus, and participates in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is nearly identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. CALR binds to antibodies in specific sera of systemic lupus and Sjogren patients which have anti-Ro/SSA antibodies, it is well conserved among species, and it is positioned in the endoplasmic and sarcoplasmic reticulum where it binds calcium. The amino terminus of CALR interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. CALR reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Therefore, CALR acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.
Uniprot IDP27797
Protein Accession #NP_004334.1
Protein Size (# AA)Recombinant
Molecular Weight49 kDa
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