CALCOCO1 Antibody - N-terminal region (ARP57483_P050)

Catalog No: ARP57483_P050

WB Suggested Anti-CALCOCO1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CALCOCO1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CALCOCO1 (ARP57483_P050) antibody is Catalog # AAP57483 (Previous Catalog # AAPP41537)

Target Info

• Gene Symbol: CALCOCO1
• Gene Full Name: Calcium binding and coiled-coil domain 1
• Alias Symbols: Cocoa, PP13275, calphoglin
• NCBI Gene Id: 57658
• Protein Name: Calcium-binding and coiled-coil domain-containing protein 1
• Description of Target: CALCOCO1 functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR).CALCOCO1 is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. CALCOCO1 is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. CALCOCO1 functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions.
• Uniprot ID: Q9P1Z2
• Protein Accession #: NP_065949
• Nucleotide Accession #: NM_020898
• Protein Size (# AA): 691
• Molecular Weight: 77kDa
• Protein Interactions: CWF19L2; CEP19; FAM161A; TBC1D15; DUSP13; ISOC1; GABARAPL2; NDC80; UBC; GRIK2; APP; APTX; EP300; CTNNB1; NEDD4; HIST1H4A; HIST1H3A; PCBD1; TBC1D17; CTNNBL1; CYTH3; SH3GL3; CRYBA2; CREBBP; MAPK1; KRT15; IPP; FOSL1;