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CADM1 Protein Lysate (APL10201)

200ug
$219.00
In Stock
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Gene Symbol:
CADM1
Alias Symbols:
BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1, MGC51880, MGC149785, DKFZp686F1789
NCBI Gene Id:
23705
Protein Name:
Cell adhesion molecule 1
Swissprot Id:
Q9BY67
Protein Accession #:
NP_001091987
Nucleotide Accession #:
NM_001098517
Description of Target:
Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Molecular Weight:
46
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express CADM1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express CADM1.
Protein Interactions:
PSMA6; UBC; ATF7IP; CADM1; EPB41L3; SDCBP; MPP3; CASK;
Quality Control:
This product was tested on western blot.
Application : Western blot standard.
Observed Molecular Weight: 46
Expression system : Bacteria
Tag:
GST in N-terminal
Reconstitution and Storage:
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-CADM1 (APL10201) antibody
Additional Information:
Buffer Formulation: 0.1M Tris-HCl (pH 6.8) buffer containing 0.2M DTT, 4% SDS, 0.2% Bromophenol blue and 20% Sucrose.

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