CADM1 Antibody - C-terminal region (ARP87472_P050)

Catalog No: ARP87472_P050

Host: Rabbit
Target Name: CADM1
Sample Tissue: Human Jurkat Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CADM1
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: LLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEY
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-CADM1 (ARP87472_P050) antibody is Catalog # AAP87472

Target Info

• Gene Symbol: CADM1
• Gene Full Name: cell adhesion molecule 1
• Alias Symbols: BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1
• NCBI Gene Id: 23705
• Protein Name: cell adhesion molecule 1
• Description of Target: Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
• Uniprot ID: Q9BY67-5
• Protein Accession #: NP_001091987.1
• Nucleotide Accession #: NM_001098517.1
• Protein Size (# AA): 414
• Molecular Weight: 45 kDa