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- $55: Antibody & Protein in US
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| Datasheets/Manuals | Printable datasheet for C4A Antibody (OASA01015) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid. Borate buffered saline |
| Clonality | Monoclonal |
| Clone | 057-51.5.1.6 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | Enzyme-linked immunosorbent assay|Immunohistochemistry-Frozen |
| Additional Information | Histology Positive Control Tissue: Kidney from post streptoccal glomerulonephritis patients |
| Reconstitution and Storage | -20°C |
| Immunogen | Purified human C4d. |
| Purification | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Predicted Homology Based on Immunogen Sequence | Human |
| Concentration | 1.1 mg/ml |
| Specificity | OASA01015 recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous. |
| Reference | 1. Rogers, J. et al. (1992) Complement Activation by beta-amyloid in Alzheimer disease. PNAS 89: 10016-10020. |
| Gene Symbol | C4A |
|---|---|
| Alias Symbols | C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2 |
| NCBI Gene Id | 720 |
| Protein Name | Complement C4-A |
| Description of Target | MOUSE ANTI HUMAN C4d (NEOANTIGEN) |
| Uniprot ID | P0C0L4 |
| Protein Accession # | NP_009224.2 |
| Protein Size (# AA) | 1744 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "C4A Antibody (OASA01015)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "C4A Antibody (OASA01015)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "C4A Antibody (OASA01015)" provided in?
This item is provided in "Liquid. Borate buffered saline".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "C4A Antibody (OASA01015)"?
This target may also be called "C4, RG, C4S, CO4, C4A2, C4A3, C4A4, C4A6, C4AD, CPAMD2" in publications.
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What is the shipping cost for "C4A Antibody (OASA01015)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "C4A Antibody (OASA01015)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "C4A Antibody (OASA01015)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "C4A Antibody (OASA01015)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "C4A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "C4A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "C4A"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "C4A"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "C4A"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "C4A"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
