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Datasheets/Manuals | Printable datasheet for C3 Antibody (OASA09139) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid. Phosphate buffered saline |
Clonality | Polyclonal |
Isotype | IgG |
Host | Sheep |
Application | Enzyme-linked immunosorbent assay|Immunohistochemistry-Frozen |
:: | Preservative Stabilisers: 0.09% Sodium Azide (NaN3) |
:: | Approx Protein Conc: IgG concentration 5.0 mg/ml Buffer Solutions: Phosphate buffered saline |
Reconstitution and Storage | -20°C |
Immunogen | Native human C3c purified from serum. |
Purification | Protein G Purified |
Predicted Homology Based on Immunogen Sequence | Human |
Concentration | 5 mg/ml |
Specificity | Sheep anti Human C3c antibody detects human complement 3c, a polypeptide fragment which is present in C3. C3 plays a central role in the activation of the complement system. Processing of C3 by C3 convertase is the central reaction in both classical and alternative complement pathways, resulting in C3a and C3b. C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates, and help to initiate the complement cascade, potentially resulting in cellular apoptosis. C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c and C3dg. Defects in C3 can result in susceptibility to pyogenic infection. This antbody shows minimal reactivity with related serum proteins. |
Application Info | Immunohistology - Frozen: 1/50 ELISA: 1/400 |
Reference | 1. Janssen, B. et al. (2005) Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 437: 505-511. |
Gene Symbol | C3 |
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Alias Symbols | ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p |
NCBI Gene Id | 718 |
Protein Name | Complement C3 |
Description of Target | SHEEP ANTI HUMAN C3c |
Uniprot ID | P01024 |
Protein Accession # | NP_000055.2 |
Protein Size (# AA) | 1663 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "C3 Antibody (OASA09139)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "C3 Antibody (OASA09139)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "C3 Antibody (OASA09139)" provided in?
This item is provided in "Liquid. Phosphate buffered saline".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "C3 Antibody (OASA09139)"?
This target may also be called "ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p" in publications.
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What is the shipping cost for "C3 Antibody (OASA09139)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "C3 Antibody (OASA09139)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "C3 Antibody (OASA09139)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "C3 Antibody (OASA09139)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "C3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "C3"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "C3"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "C3"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "C3"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "C3"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.