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REL Antibody (Ascites) (OAAB06845)

0.1 ml
$390.00
In Stock
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Gene Symbol:
REL
NCBI Gene Id:
5966
Protein Name:
Proto-oncogene c-Rel
Swissprot Id:
Q04864
Protein Accession #:
NP_002899.1
Alias Symbols:
REL, Proto-oncogene c-Rel
Replacement Item:
This antibody may replace item sc-272 from Santa Cruz Biotechnology.
Description of Target:
Mouse Monoclonal Antibody (Mab)
Molecular Weight:
68520 Da
Host:
Mouse
Clonality:
Monoclonal
Application:
WB, IF
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express REL.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express REL.
Immunogen:
This REL monoclonal antibody is generated from mouse immunized with REL recombinant protein.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for OAAB06845
Clone:
318CT41.3.2
Isotype:
IgG2b
Application Info:
WB: 1:500~16000
IF: 1:10~50
Additional Information:
Precautions: C-rel Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator
:::
Cellular Location: Nucleus (By similarity).

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