BST2 Antibody (OACA06875)

Catalog No: OACA06875

Immunohistochemistry of paraffin-embedded human liver at dilution 1:100

Immunohistochemistry of paraffin-embedded human placenta at dilution 1:100

Immunohistochemistry of paraffin-embedded human liver at dilution 1:100

Immunohistochemistry of paraffin-embedded human placenta at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Bone marrow stromal antigen 2 protein (49-161AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Structural insight into the mechanisms of enveloped virus tethering by tetherin." Yang H., Wang J., Jia X., McNatt M.W., Zang T., Pan B., Meng W., Wang H.W., Bieniasz P.D., Xiong Y.Proc. Natl. Acad. Sci. U.S.A. 107:18428-18432(2010). [2]"Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations."Schubert H.L., Zhai Q., Sandrin V., Eckert D.M., Garcia-Maya M., Saul L., Sundquist W.I., Steiner R.A., Hill C.P.Proc. Natl. Acad. Sci. U.S.A. 107:17951-17956(2010). [3]"Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain." Hinz A., Miguet N., Natrajan G., Usami Y., Yamanaka H., Renesto P., Hartlieb B., McCarthy A.A., Simorre J.P., Gottlinger H., Weissenhorn W.Cell Host Microbe 7:314-323(2010).

Target Info

• Gene Symbol: BST2
• Gene Full Name: bone marrow stromal cell antigen 2
• Alias Symbols: antiviral factor tetherin;bone marrow stromal antigen 2;BST-2;CD317;HM1.24;HM1.24 antigen;NPC-A-7;TETHERIN.
• NCBI Gene Id: 684
• Protein Name: Bone marrow stromal antigen 2
• Description of Target: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328).
• Uniprot ID: Q10589
• Protein Accession #: NP_004326
• Nucleotide Accession #: NM_004335