BRCC3 Antibody - C-terminal region (ARP61990_P050)

Catalog No: ARP61990_P050

WB Suggested Anti-BRCC3 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Heart

Host: Rabbit
Target Name: BRCC3
Sample Type: Human Hela
Antibody Dilution: 1.0ug/mlBRCC3 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells

Sample Type:
MCF7
Primary Antibody Dilution:
4 ug/ml
Secondary Antibody:
Anti-rabbit Alexa 546
Secondary Antibody Dilution:
2 ug/ml
Gene Name:
BRCC3

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IF, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 86%
• Peptide Sequence: Synthetic peptide located within the following region: HNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQEL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-BRCC3 (ARP61990_P050) antibody is Catalog # AAP61990
• Sample Type Confirmation:

  BRCC3 is strongly supported by BioGPS gene expression data to be expressed in HeLa

Target Info

• Gene Symbol: BRCC3
• Gene Full Name: BRCA1/BRCA2-containing complex, subunit 3
• Alias Symbols: C6.1A, BRCC36, CXorf53
• NCBI Gene Id: 79184
• Protein Name: Lys-63-specific deubiquitinase BRCC36
• Description of Target: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy.
• Uniprot ID: P46736
• Protein Accession #: NP_077308
• Nucleotide Accession #: NM_024332
• Protein Size (# AA): 316
• Molecular Weight: 35kDa
• Protein Interactions: FAM175B; UBC; FANCG; UIMC1; SUMO1; RABEP2; SMEK1; LARP7; CD2AP; WDHD1; SF3A1; GPHN; HNRNPR; TRIM28; HUWE1; MTA2; SPAG9; CCDC6; HDAC1; NR3C1; FAM175A; SUMO2; PAXIP1; MDC1; BRCA1; GRB2; BABAM1; BRE; BRCC3; COPS5; BACH1; BRCA2; BARD1; USP7; SHMT2; NDUFA10; M