Catalog No: OPCD01715
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OPCD01715
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Datasheets/ManualsPrintable datasheet for BRCA2 Recombinant Protein (OPCD01715)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Glu2990-Ala3232
::Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His Tag
Gene SymbolBrca2
Gene Full Namebreast cancer 2, early onset
Alias Symbolsbreast cancer type 2 susceptibility protein homolog;Fanc;Fancd1;fanconi anemia group D1 protein homolog;RAB1;RAB163.
NCBI Gene Id12190
Protein NameBreast cancer type 2 susceptibility protein homolog
Description of TargetInvolved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).
Uniprot IDP97929
Protein Accession #NP_001074470.1
Nucleotide Accession #NM_001081001.2
Protein Size (# AA)Glu2990~Ala3232
Molecular Weight30kDa
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