Size:100 ul
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Conjugation Options

AVARP02017_P050-FITC Conjugated

AVARP02017_P050-HRP Conjugated

AVARP02017_P050-Biotin Conjugated

BRCA1 Antibody - N-terminal region (AVARP02017_P050)

Catalog#: AVARP02017_P050
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More Information
Tested Species Reactivity Human
Predicted Species Reactivity Dog, Human, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application IHC, WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human BRCA1
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Dog: 92%; Human: 100%; Rat: 76%
Complete computational species homology data Anti-BRCA1 (AVARP02017_P050)
Peptide Sequence Synthetic peptide located within the following region: MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLK
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-BRCA1 (AVARP02017_P050) antibody is Catalog # AAP30434 (Previous Catalog # AAPP01017)
Datasheets/Manuals Printable datasheet for anti-BRCA1 (AVARP02017_P050) antibody
Sample Type Confirmation

BRCA1 is supported by BioGPS gene expression data to be expressed in K562

Target Reference Mark,W.Y., et al., (2005) J. Mol. Biol. 345 (2), 275-287

Kim, J.-H., Yu, C.-H., Yhee, J.-Y., Im, K.-S. & Sur, J.-H. Lymphocyte infiltration, expression of interleukin (IL) -1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours. J. Comp. Pathol. 142, 177-86 (2010). IHC, WB, Dog, Human, Rat 19959182

Gene Symbol BRCA1
Official Gene Full Name Breast cancer 1, early onset
NCBI Gene Id 672
Protein Name Breast cancer type 1 susceptibility protein
Description of Target BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.
Swissprot Id P38398
Protein Accession # NP_009229
Nucleotide Accession # NM_007298
Protein Size (# AA) 680
Molecular Weight 76kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express BRCA1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express BRCA1.
Protein Interactions RAD50; MED17; RAD51; YAP3; HDA3; SSN3; BEM4; GYP5; YAF9; HDAC2; MSH6; BAP1; SUPT5H; POLR2A; NPR1; NUP53; MET18; CDC21; MLP1; CTK1; MSH2; BACH1; DAN1; TMA22; BBC1; RPB4; SPT4; YGR053C; ATE1; YBP2; SLI15; RAD16; XRS2; RAD55; BUR2; BRIP1; ESR1; BECN1; HIST1H
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