BPIFA1 Antibody - middle region (OASG05992)

Catalog No: OASG05992

Size:100 uL

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
  Tissue Specificity: Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.
  Sequence & Domain Family: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
  Cellular Localization: Secreted.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human PLUNC.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: May be N-glycosylated.
• Specificity: PLUNC Polyclonal Antibody detects endogenous levels of PLUNC protein.
• Application Info: IHC: 1:100~300
  ELISA: 1:40000

Target Info

• Gene Symbol: BPIFA1
• Gene Full Name: BPI fold containing family A, member 1
• Alias Symbols: LUNX, NASG, PLUNC, SPURT, SPLUNC1, bA49G10.5
• NCBI Gene Id: 51297;
• Description of Target: Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
• Uniprot ID: Q9NP55
• Molecular Weight: 27 kDa