BNK Recombinant Protein (Fruit fly) (OPCA03352)

Catalog No: OPCA03352

bnk Recombinant Protein (Drosophila melanogaster) (OPCA03352) in SDS-PAGE showing the molecular weight of approximately 37.64 kDa.

Product Info

• Predicted Species Reactivity: Drosophila melanogaster
• Product Format: Liquid or Lyophilized powder
• Host: Drosophila melanogaster
• Additional Information: Relevance: Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
• Reconstitution and Storage: -20°C or -80°C
• Formulation: 20 mM Tris-HCl based buffer, pH 8.0
• Purity: Greater than 90% as determined by SDS-PAGE.
• Peptide Sequence: MSISTFNFQFYNYKLSPSSPGFGSTASRSSSSCISELEMDIDEDMSAQPTITSTPKPRFTSQLAVELAKTEPGNGISPLRPKLHTAQKRWSMELREKVLEMSKRNNGQEKPQTARQQEQRQPQEQPLQQEELQHQQQEPTVTDKINFFNKLTNTFESGFSKLMPQASSTNNRFIAMLRTARPQNVATTTANSSTANSFLGSDHSLSGSVTGQVPPPKPKRLSATTAQFATPHVPAMGVGKGGSQRKCSLRRKPSMDKSRATISRQSSSASVRTQNHAIMEDLSLVVPVRLRIAEYEQRISMSA
• Protein Sequence: MSISTFNFQFYNYKLSPSSPGFGSTASRSSSSCISELEMDIDEDMSAQPTITSTPKPRFTSQLAVELAKTEPGNGISPLRPKLHTAQKRWSMELREKVLEMSKRNNGQEKPQTARQQEQRQPQEQPLQQEELQHQQQEPTVTDKINFFNKLTNTFESGFSKLMPQASSTNNRFIAMLRTARPQNVATTTANSSTANSFLGSDHSLSGSVTGQVPPPKPKRLSATTAQFATPHVPAMGVGKGGSQRKCSLRRKPSMDKSRATISRQSSSASVRTQNHAIMEDLSLVVPVRLRIAEYEQRISMSA
• Storage Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Source: E.coli
• Protein Range: 1-303 aa
• Tag: N-terminal 6xHis-tagged

Target Info

• Reference: Bottleneck acts as a regulator of the microfilament network governing cellularization of the Drosophila embryo.Schejter E.D., Wieschaus E.Cell 75:373-385(1993)
• Gene Symbol: bnk
• Gene Full Name: bottleneck
• Alias Symbols: Bnk;bnk-PA;bottleneck;CG1480;CG1480-PA;Dmel\CG1480;Dmel_CG1480.
• NCBI Gene Id: 43687
• Protein Name: Protein bottleneck
• Description of Target: Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions.
• Uniprot ID: P40794
• Protein Accession #: NP_524604.2
  
• Nucleotide Accession #: NM_079865.4
• Protein Size (# AA): Recombinant
• Molecular Weight: 37.6 kDa