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BMP2 Antibody (OASA07470)

50 ug
$395.00
In Stock
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Gene Symbol:
BMP2
NCBI Gene Id:
650
Protein Name:
Bone morphogenetic protein 2
Swissprot Id:
P12643
Protein Accession #:
NP_001191.1
Alias Symbols:
BMP2A, BMP2
Replacement Item:
This antibody may replace item sc-128103 from Santa Cruz Biotechnology.
Description of Target:
RABBIT ANTI HUMAN BMP-2
Protein Size (# AA):
396
Host:
Rabbit
Clonality:
Polyclonal
Application:
ELISA, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BMP2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BMP2.
Immunogen:
The immunogen for anti-BMP2 antibody: recombinant human BMP-2.
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified IgG - liquid
Reconstitution and Storage:
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Datasheets/Manuals:
Printable datasheet for anti-BMP2 antibody - OASA07470
Specificity:
BMP-2
Isotype:
Polyclonal IgG
Application Info:
Dilution: 0.25 ug/ml. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
:::
Preservative Stabilisers: 0.09% - Sodium Azide (NaN3)
Antiserum Preparation: Antisera to human BMP-2 were raised by repeated immunisations of rabbits with highly purified antigen.
:::
Approx Protein Conc: IgG concentration 1.0mg/ml
Buffer Solutions: Phosphate buffered saline pH7.4.
Target Reference:
1. Balemans, W. and Van Hul, W. (2002) Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev. Biol. 250: 231-250.
2. Sebald, W. et al. (2004) Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. Biol. Chem. 385: 697-710.
3. Keller, S. et al. (2004) Molecular recognition of BMP-2 and BMP receptor IA. Nature Structural and Molecular Biology. 11: 481-488.
4. Kirsch, T. et al. (2000) BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. EMBO J. 19: 3314-3324.
5. Kimura, N. et al. (2000) BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J. Biol. Chem. 275: 17647-17652.

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