BLNK Recombinant Protein (OPCD01651)

Catalog No: OPCD01651

BLNK Recombinant Protein (OPCD01651) using SDS-PAGE

BLNK Recombinant Protein (OPCD01651) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser65-Thr314
  Subcellular Location: Cytoplasm. Cell membrane
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: BLNK
• Gene Full Name: B cell linker
• Alias Symbols: AGM4;B cell adaptor containing SH2 domain;BASH;bca;B-cell activation;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;B-cell linker protein;BLNK-S;cytoplasmic adapter protein;LY57;SLP65;SLP-65;Src homology [SH2] domain-containing leukocyte protein of 65 kD;Src homology 2 domain-containing leukocyte protein of 65 kDa.
• NCBI Gene Id: 29760
• Protein Name: B-cell linker protein
• Description of Target: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
• Uniprot ID: Q8WV28
• Protein Accession #: NP_001107566.1
• Nucleotide Accession #: NM_001114094.1
• Protein Size (# AA): Ser65~Thr314
• Molecular Weight: 32kDa