BLNK Antibody (Phospho-Tyr84) (OASG00778)

Catalog No: OASG00778

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human BLNK around the phosphorylation site of Y84. Location: 20-100aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr84
• Specificity: Phospho-BLNK (Tyr84) Polyclonal Antibody detects endogenous levels of BLNK protein only when phosphorylated at Y84.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: BLNK
• Gene Full Name: B-cell linker
• Alias Symbols: bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65
• NCBI Gene Id: 29760; 17060; 499356
• Description of Target: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
• Uniprot ID: Q8WV28, Q9QUN3, Q4KM52
• Molecular Weight: 65 kDa