Catalog No: OPCD01647
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OPCD01647
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Datasheets/ManualsPrintable datasheet for BLK Recombinant Protein (OPCD01647)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Leu241-Tyr494
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity>95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolBLK
Gene Full NameBLK proto-oncogene, Src family tyrosine kinase
Alias Symbolsb lymphocyte kinase;B lymphoid tyrosine kinase;BLK nonreceptor tyrosine kinase;MODY11;p55-Blk;tyrosine-protein kinase Blk.
NCBI Gene Id640
Protein NameTyrosine-protein kinase Blk
Description of TargetNon-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
Uniprot IDP51451
Protein Accession #NP_001706.2
Nucleotide Accession #NM_001715.2
Protein Size (# AA)Leu241~Tyr494
Molecular Weight32.7kDa
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