BLK Antibody (OACA07128)

Catalog No: OACA07128

Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Tyrosine-protein kinase Blk protein (1-280AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007). [2]"Initial characterization of the human central proteome."Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011). [3]"Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction."Borowiec M., Liew C.W., Thompson R., Boonyasrisawat W., Hu J., Mlynarski W.M., El Khattabi I., Kim S.H., Marselli L., Rich S.S., Krolewski A.S., Bonner-Weir S., Sharma A., Sale M., Mychaleckyj J.C., Kulkarni R.N., Doria A.Proc. Natl. Acad. Sci. U.S.A. 106:14460-14465(2009).

Target Info

• Gene Symbol: BLK
• Gene Full Name: BLK proto-oncogene, Src family tyrosine kinase
• Alias Symbols: b lymphocyte kinase;B lymphoid tyrosine kinase;BLK nonreceptor tyrosine kinase;MODY11;p55-Blk;tyrosine-protein kinase Blk.
• NCBI Gene Id: 640
• Protein Name: Tyrosine-protein kinase Blk
• Description of Target: Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
• Uniprot ID: P51451
• Protein Accession #: NP_001706
• Nucleotide Accession #: NM_001715