- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
| Datasheets/Manuals | Printable datasheet for anti-BIRC5 (OAED00011) antibody |
|---|
| Predicted Species Reactivity | Human, Mouse, Rat |
|---|---|
| Clonality | Monoclonal |
| Clone | 60.11 |
| Isotype | IgG2a |
| Host | Mouse |
| Application | IHC, WB |
| Reconstitution and Storage | Long Term Storage : -20C |
| Immunogen | Recombinant human Survivin protein (full length). |
| Specificity | Recognizes human, mouse and rat Survivin. |
| Formulation | Liquid. In PBS containing 0.1% sodium azide. Concentration 1mg/ml. |
| Purity | Protein G affinity purified. |
| Application Info | Immunohistochemistry Western Blot Optimal conditions must be determined individually for each application. |
| Gene Symbol | BIRC5 |
|---|---|
| Gene Full Name | Baculoviral IAP repeat-containing protein 5 |
| Alias Symbols | API4, EPR-1 |
| NCBI Gene Id | 332 |
| Protein Name | Baculoviral IAP repeat-containing protein 5 |
| Description of Target | Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy. |
| Uniprot ID | O15392 |
| Protein Accession # | NP_001012270.1; NP_001012271.1; NP_001159.2 |
| Nucleotide Accession # | NM_001012270.1; NM_001012271.1; NM_001168.2 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "BIRC5 Antibody (OAED00011)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
-
How long will it take to receive "BIRC5 Antibody (OAED00011)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".
-
What buffer format is "BIRC5 Antibody (OAED00011)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "BIRC5 Antibody (OAED00011)"?
This target may also be called "API4, EPR-1" in publications.
-
What is the shipping cost for "BIRC5 Antibody (OAED00011)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "BIRC5 Antibody (OAED00011)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "BIRC5 Antibody (OAED00011)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "BIRC5 Antibody (OAED00011)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "BIRC5"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "BIRC5"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "BIRC5"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "BIRC5"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "BIRC5"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "BIRC5"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
