Size:100ug
$350.00
Discontinued
SKU
OASE00384
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Conjugation Options

OASE00384-FITC Conjugated

OASE00384-HRP Conjugated

OASE00384-Biotin Conjugated

BIM/BOD (IN2) Antibody (OASE00384)

Catalog#: OASE00384
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This product is Genway GWB-0X0023
More Information
Predicted Species Reactivity Human, Mouse, Rat
Clonality Polyclonal
Host Rabbit
Application WB, ICC
Additional Information Background Info: Detects a 23kDa protein corresponding to the molecular mass of Bim on SDS PAGE immunoblots.
:: Scientific Background: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively.
Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).
:: Certificate of Analysis: 2.5 ug/mL was sufficient for detection of Bim in 20ug of K562 cell lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Reconstitution and Storage Store at -20C. Shipping in Blue Ice or 4C.
Replacement Item This antibody may replace item sc-11425 from Santa Cruz Biotechnology.
Immunogen Internal central amino acids of human Bim
Purification Affinity Purified
Concentration 1mg/mL
Datasheets/Manuals Printable datasheet for OASE00384
Dilution 1:400 (WB), 1:100 (ICC)
Target Reference 1. O'Connor L, Strasser A, O'Reilly LA, et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998; 17:384-395.
2. Hsu SY, Lin P, and Hsueh AJ BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol. Endocrinol. 1998; 12:1432-40.
Storage Buffer PBS with 0.02% sodium azide
Gene Symbol BCL2L11
Official Gene Full Name BCL2-like 11 (apoptosis facilitator)
NCBI Gene Id 10018
Swissprot Id O43521
Protein Accession # NP_619527.1
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express BCL2L11.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express BCL2L11.
  1. What is the species homology for "BIM/BOD (IN2) Antibody (OASE00384)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "BIM/BOD (IN2) Antibody (OASE00384)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "BIM/BOD (IN2) Antibody (OASE00384)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "BIM/BOD (IN2) Antibody (OASE00384)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "BIM/BOD (IN2) Antibody (OASE00384)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "BIM/BOD (IN2) Antibody (OASE00384)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "BIM/BOD (IN2) Antibody (OASE00384)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "BIM/BOD (IN2) Antibody (OASE00384)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "BCL2L11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "BCL2L11"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "BCL2L11"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "BCL2L11"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "BCL2L11"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "BCL2L11"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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