BID Protein (OPPA01723)

Catalog No: OPPA01723 (Formerly GWB-D4954C)

Size:2UG

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: The Mouse BID protein solution contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl. Physical appearance: Sterile Filtered colorless liquid formulation.
• Host: E. Coli
  Product Introduction: BID is a pro-apoptotic Bcl-2 protein having only the BH3 domain. In reaction to apoptotic signaling, BID interacts with another Bcl-2 family of cell death regulators, called Bax, they form a heterodimer resulting to the insertion of Bax into the outer mitochondrial membrane. Bax induces the opening of the mitochondrial voltage-dependent anion channel which lead to the release of cytochrome c and other pro-apoptotic factors from the mitochondria resulting in activation of caspases. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. The major proteolytic product p15 BID releasea cytochrome c. Isoform 1, Isoform 2 and Isoform 4 induce ice-like proteases and apoptosis while Isoform 3 does not induce apoptosis.
  Product Description: BID Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 1-195 amino acids and having a molecular mass of 22 kDa.
• Reconstitution and Storage: BID although stable at 15C for 1 week, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Target Info

• Gene Symbol: mBID
• Alias Symbols: AI875481, AU022477, 2700049M22Rik
• NCBI Gene Id: 12122
• Protein Name: BH3-interacting domain death agonist
• Description of Target: Recombinant Mouse BH3 Interacting Domain Death Agonist
• Uniprot ID: P70444
• Protein Accession #: NP_031570.2
• Protein Size (# AA): Recombinant