BICD2 Antibody (OAPB00707)

Catalog No: OAPB00707

Size:100UG

Western blot analysis of BICD2 in A549 cell lysate with BICD2 antibody at (A) 1 and (B) 2 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. BICD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: BICD2 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: BICD2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human BICD2. The immunogen is located within the last 50 amino acids of BICD2.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-BICD2 antibody is Catalog # OEPB02828
• Application Info: BICD2 antibody can be used for detection of BICD2 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Holland PM, Milne A, Garka K, et al. Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. J. Biol. Chem.2002; 277:16229-40.;Hoogenraad CC, Akhmanova A, Howell SA, et al. Mammalian golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. EMBO J.2001; 4041-54.;Teuling E, van Dis V, Wulf PS, et al. A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice. Hum. Mol. Genet.2008; 17:2849-62.;

Target Info

• Gene Symbol: BICD2
• Gene Full Name: BICD cargo adaptor 2
• Alias Symbols: bA526D8.1;bicaudal D homolog 2;bic-D 2;coiled-coil protein BICD2;cytoskeleton-like bicaudal D protein homolog 2;homolog of Drosophila bicaudal D;protein bicaudal D homolog 2;SMALED2;SMALED2A;SMALED2B.
• NCBI Gene Id: 23299
• Protein Name: bicaudal D homolog 2 (Drosophila) [Homo sapiens]|Protein bicaudal D homolog 2
• Description of Target: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).
• Uniprot ID: Q8TD16
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/CAI41013