BICC1 Antibody - N-terminal region (OAAB04089)

Catalog No: OAAB04089 (Formerly GWB-ABBFUN)

Size:400ul

Western blot analysis of BICC1 Antibody (N-term) (Cat. #OAAB04089) in HL-60 cell line lysates (35ug/lane). BICC1 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human brain tissue reacted with BICC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse, Xenopus
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC-P
• Additional Information: Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
  Cellular Location: Cytoplasm
  
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: 0.47 mg/ml
• Intended Use: For research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50
  Optimal dilutions should be determined by the end user.
• Reference: Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
• Publications:

  Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. PLoS Genet. 13, e1006694 (2017). 28406902

Target Info

• Gene Symbol: BICC1
• Alias Symbols: BICC, CYSRD
• NCBI Gene Id: 80114
• Protein Name: Protein bicaudal C homolog 1
• Description of Target: BICC1 is an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
• Uniprot ID: Q9H694
• Protein Accession #: NP_001073981.1
• Molecular Weight: 105 kDa