BI-2536 (OOMC00065)

Catalog No: OOMC00065

Product Info

• Product Format: Powder
• Additional Information: CAS: 755038-02-9
  Molecular Formula: C28H39N7O3
  Chemical Name: 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
  Primary Activity: Kinase inhibitor: Plk/BRD4
  COVID-19 Rationale: SARS-CoV-2 transmembrane protein E binds to the bromodomain-containing proteins BRD2 and BRD4
• Reconstitution and Storage: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml). Store at -20C.
• Purity: > 97%
• Reference: 1) Steegmaier et al. (2007), BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo; Curr.Biol., 17 316 2) Davis et al. (2011), Comprehensive analysis of kinase inhibitor selectivity; Nat.Biotechnol., 29 1046 3) Ciceri et al. (2014), Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat.Chem.Biol., 10 305 4) Xiao et al. (2016), Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival; Mol.Cell, 64 493

Target Info

• Molecular Weight: 521.67 g/mol