BEX1 Antibody - middle region (OAAB00716)

Catalog No: OAAB00716

Size:400ul

BEX1 Antibody (Center) western blot analysis in WiDr cell lysates (35ug/lane).This demonstrates the BEX1 antibody detected the BEX1 protein (arrow).

BEX1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the BEX1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

BEX1 Antibody (Center) (Cat. # OAAB00716) flow cytometric analysis of WiDr cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: WB, IHC-P, FC
  Cellular Location: Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus.
  Tissue Location: Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This BEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the Central region of human BEX1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Monkey
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: IHC-P: 1:50~100
  FC: 1:10~50

Target Info

• Gene Symbol: BEX1
• Alias Symbols: BEX2, HBEX2, HGR74-h
• NCBI Gene Id: 55859
• Protein Name: Protein BEX1
• Description of Target: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
• Uniprot ID: Q9HBH7
• Protein Accession #: NP_060946.3
• Molecular Weight: 15 kDa