beta TrCP2 CONTROL PEPTIDE (OERA00080)

Catalog No: OERA00080

Size:50UG

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Liquid (sterile filtered)
• Conjugation: Unconjugated
• Reconstitution and Storage: 2°C to 8°C|-20°C
• Concentration: 1 mg/ml

Target Info

• Gene Symbol: FBXW11
• Gene Full Name: F-box and WD repeat domain containing 11
• Alias Symbols: beta-transducin repeat-containing protein 2;BTRC2;BTRCP2;F-box and WD repeats protein beta-TrCP2;F-box and WD-40 domain protein 11;F-box and WD-40 domain protein 1B;F-box protein Fbw1b;F-box/WD repeat-containing protein 11;F-box/WD repeat-containing protein 1B;Fbw11;FBW1B;FBXW1B;homologous to Slimb protein;Hos;NEDJED.
• NCBI Gene Id: 23291
• Protein Name: F-box/WD repeat-containing protein 11
• Description of Target: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262).
• Uniprot ID: Q9UKB1