Catalog No: OAPB00348
Size:100UG
Price: $461.00
SKU
OAPB00348
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for BECN1 Antibody (OAPB00348) (OAPB00348)
Product Info
Predicted Species ReactivityBovine|Human|Mouse|Porcine|Rat
Product FormatLiquid. Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
::Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and Storage2°C to 8°C
ImmunogenAnti-Beclin-1 antibody (3613) was raised against a peptide corresponding to 17 amino acids near the center of human Beclin-1. The immunogen is located between 40-90 amino acids of Beclin-1.
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman; Mouse; Rat
Concentration1 mg/ml
Blocking PeptideFor anti-BECN1 (OAPB00348) antibody is Catalog # OEPB02438
Application InfoBeclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5-2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. Optimal dilutions for each application to be determined by the researcher.
ReferenceGozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004; 23:2891-906.;
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.;
Liang XH, Kleeman LK, Jiang HH, et al. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J. Virol. 1998; 72:8586-96.;
Kametaka S, Okano T, Ohsumi M, et al. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 1998; 273:22284-91.
Gene SymbolBECN1
Gene Full Namebeclin 1
Alias SymbolsATG6;ATG6 autophagy related 6 homolog;beclin 1 (coiled-coil, moesin-like BCL2-interacting protein);beclin 1, autophagy related;beclin1;beclin-1;coiled-coil myosin-like BCL2-interacting protein;Protein GT197;testis secretory sperm-binding protein Li 215e;VPS30.
NCBI Gene Id8678
Protein NameBeclin 1, autophagy related [Homo sapiens]|Beclin-1
Description of TargetPlays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Uniprot IDQ14457
Protein Accession #https://www.ncbi.nlm.nih.gov/protein/AAH10276
Nucleotide Accession #NM_003766.3; XM_005257758.2
Molecular WeightPredicted: 52 kD Observed: 60 kD
  1. What is the species homology for "BECN1 Antibody (OAPB00348)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Bovine|Human|Mouse|Porcine|Rat".

  2. How long will it take to receive "BECN1 Antibody (OAPB00348)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "BECN1 Antibody (OAPB00348)" provided in?

    This item is provided in "Liquid. Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "BECN1 Antibody (OAPB00348)"?

    This target may also be called "ATG6;ATG6 autophagy related 6 homolog;beclin 1 (coiled-coil, moesin-like BCL2-interacting protein);beclin 1, autophagy related;beclin1;beclin-1;coiled-coil myosin-like BCL2-interacting protein;Protein GT197;testis secretory sperm-binding protein Li 215e;VPS30." in publications.

  5. What is the shipping cost for "BECN1 Antibody (OAPB00348)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "BECN1 Antibody (OAPB00348)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "BECN1 Antibody (OAPB00348)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "Predicted: 52 kD Observed: 60 kD".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "BECN1 Antibody (OAPB00348)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "BECN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "BECN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "BECN1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "BECN1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "BECN1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "BECN1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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