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BECN1 Antibody (Ascites) (OAAB06659)

0.1 ml
$390.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Clonality:
Monoclonal
Clone:
117CT2.5.1.1
Isotype:
IgM,K
Host:
Mouse
Application:
WB, IHC-P, IF
:::
Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Cellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity)
Tissue Location: Ubiquitous.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
BECN1
NCBI Gene Id:
8678
Protein Name:
Beclin-1
Swissprot Id:
Q14457
Protein Accession #:
NP_003757.1
Alias Symbols:
BECN1, GT197, Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197
Replacement Item:
This antibody may replace item sc-10086, HPA028949
Description of Target:
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).
Molecular Weight:
51896 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BECN1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BECN1.
Immunogen:
This BECN1 Monoclonal antibody was raised using purified His-tagged recombinant full length human Autophagy BECN1.
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for OAAB06659
Application Info:
WB: 1:100~400
IHC-P: 1:50~100
IF: 1:10~50
Intended Use:
For research use only and not for use in diagnostic or therapeutic procedures.

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