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BDNF Antibody - middle region (ARP41970_P050)

100 ul
$319.00
In Stock
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Conjugation Options

ARP41970_P050-FITC Conjugated

ARP41970_P050-HRP Conjugated

ARP41970_P050-Biotin Conjugated

Gene Symbol:
BDNF
Official Gene Full Name:
Brain-derived neurotrophic factor
NCBI Gene Id:
627
Protein Name:
Brain-derived neurotrophic factor
Swissprot Id:
P23560
Protein Accession #:
NP_001700
Nucleotide Accession #:
NM_001709
Alias Symbols:
MGC34632
Replacement Item:
This antibody may replace item sc-20981 from Santa Cruz Biotechnology.
Description of Target:
BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression BDNF is reduced in both Alzheimer's and Huntington disease patients. BDNF may play a role in the regulation of stress response and in the biology of mood disorders.The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
Protein Size (# AA):
247
Molecular Weight:
27kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BDNF.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BDNF.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human BDNF
Predicted Species Reactivity:
Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Tested Species Reactivity:
Human, Mouse, Monkey
Predicted Homology Based on Immunogen Sequence:
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Complete computational species homology data:
Anti-BDNF (ARP41970_P050)
Peptide Sequence:
Synthetic peptide located within the following region: EWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; AGO3; INPP5K; F11R; JUNB; APP; ELAVL1; Ntrk2; CADPS2; MBTPS1; SORT1; NOS3; NTF4; NTF3; ESR1; NCAM1; CPE; BDNF;
Blocking Peptide:
For anti-BDNF (ARP41970_P050) antibody is Catalog # AAP41970 (Previous Catalog # AAPS11111)
Datasheets/Manuals:
Printable datasheet for anti-BDNF (ARP41970_P050) antibody
Target Reference:
Hashimoto,R., (2008) Neurosci. Res. 61 (4), 360-367
Publications:

Horibe, I. et al. Induction of melanogenesis by 4’-O-methylated flavonoids in B16F10 melanoma cells. J. Nat. Med. 67, 705-10 (2013). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 23242310

Kasemeier-Kulesa, JC; Morrison, JA; Lefcort, F; Kulesa, PM; TrkB/BDNF signalling patterns the sympathetic nervous system. 6, 8281 (2015). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 26404565

Kight, KE; McCarthy, MM; Sex differences and estrogen regulation of BDNF gene expression, but not propeptide content, in the developing hippocampus. 95, 345-354 (2017). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 27870444

McCarthy, D. M. et al. Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J. Neurosci. 31, 13400-11 (2011). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 21940433

McCarthy, DM; Bell, GA; Cannon, EN; Mueller, KA; Huizenga, MN; Sadri-Vakili, G; Fadool, DA; Bhide, PG; Reversal Learning Deficits Associated with Increased Frontal Cortical Brain-Derived Neurotrophic Factor Tyrosine Kinase B Signaling in a Prenatal Cocaine Exposure Mouse Model. 38, 354-364 (2016). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 27951531

McCarthy, DM; Mueller, KA; Cannon, EN; Huizenga, MN; Darnell, SB; Bhide, PG; Sadri-Vakili, G; Prenatal Cocaine Exposure Alters BDNF-TrkB Signaling in the Embryonic and Adult Brain. 38, 365-374 (2016). IHC, WB, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat 28132054

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