BCL2L1 Antibody (Phospho-Thr115) (OASG00743)

Catalog No: OASG00743

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Bcl-x around the phosphorylation site of T115. Location: 50-130aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr115
• Specificity: Phospho-Bcl-x (T115) Polyclonal Antibody detects endogenous levels of Bcl-x protein only when phosphorylated at T115.
• Application Info: IHC 1:100-1:300; ELISA 1:5000;

Target Info

• Gene Symbol: BCL2L1
• Gene Full Name: BCL2-like 1
• Alias Symbols: BCLX, BCL2L, Bcl-X, PPP1R52, BCL-XL/S
• NCBI Gene Id: 598; 12048; 24888
• Description of Target: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
• Uniprot ID: Q07817, Q64373, P53563
• Molecular Weight: 24 kDa