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BCL2 Antibody - N-terminal region : FITC (AVARP01005_P050-FITC)

100 ul
$289.00
In Stock
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Conjugation Options

AVARP01005_P050 Unconjugated

AVARP01005_P050-HRP Conjugated

AVARP01005_P050-Biotin Conjugated

Gene Symbol:
BCL2
Official Gene Full Name:
B-cell CLL/lymphoma 2
NCBI Gene Id:
596
Protein Name:
Apoptosis regulator Bcl-2
Swissprot Id:
P10415
Protein Accession #:
NP_000624
Nucleotide Accession #:
NM_000633
Alias Symbols:
Bcl-2, PPP1R50
Replacement Item:
This antibody may replace item sc-130307 from Santa Cruz Biotechnology.
Description of Target:
The BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.
Protein Size (# AA):
239
Molecular Weight:
26kDa
Host:
Rabbit
Clonality:
Polyclonal
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BCL2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BCL2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human BCL2
Predicted Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Human: 100%
Complete computational species homology data:
Anti-BCL2 (AVARP01005_P050)
Peptide Sequence:
Synthetic peptide located within the following region: GHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDD
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
1 mg/ml
Protein Interactions:
KEAP1; SQSTM1; BECN1; UBC; TP53BP2; BID; BCL2L1; BCL2; BAX; BAD; ATP2A3; NR4A1; KRAS; PPID; MDM4; BNIP3; BFAR; CDK1; BAG3; RAF1; IKBKG; TP53; PPP3CC; FKBP8; MAPK8; IKBKB; HSP90AA1; HIF1A; CRYAB; CHUK; PML; BRCA1; AMBRA1; ATG12; BIK; CISD2; MEX3D; PPP1CC;
Blocking Peptide:
For anti-BCL2 (AVARP01005_P050-FITC) antibody is Catalog # AAP30327 (Previous Catalog # AAPP00708)
Datasheets/Manuals:
Printable datasheet for anti-BCL2 (AVARP01005_P050-FITC) antibody
Conjugation:
FITC (FAM): Excitation 495 nm/ Emission 520 nm
Target Reference:
Chen,R., et al., (2004) J. Cell Biol. 166 (2), 193-203

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