Bcl2 Antibody - FITC Conjugated (OACA00176)

Catalog No: OACA00176

Size:100ug

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: FITC
• Application: WB
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Mouse Apoptosis regulator Bcl-2 protein (5-205AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma.'Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M.Cell 49:455-463(1987)
  [2] Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.'Eguchi Y., Ewert D.L., Tsujimoto Y.Nucleic Acids Res. 20:4187-4192(1992)
  [3] Lineage-specific biology revealed by a finished genome assembly of the mouse.'Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: Bcl2
• Gene Full Name: B cell leukemia/lymphoma 2
• Alias Symbols: apoptosis regulator Bcl-2;AW986256;Bcl-;Bcl-2;C430015F12Rik;D630044D05Rik;D830018M01Rik.
• NCBI Gene Id: 12043
• Protein Name: Apoptosis regulator Bcl-2
• Description of Target: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
• Uniprot ID: P10417