BAP1 Antibody (Phospho-Ser592) (OABF01154)

Catalog No: OABF01154

Size:100UL

Formalin-fixed and paraffin embedded rat testis labeled with Rabbit Anti Phospho-BAP1 (Ser592) Polyclonal Antibody, Unconjugated (OABF01154) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded rat testis labeled with Rabbit Anti Phospho-BAP1 (Ser592) Polyclonal Antibody, Unconjugated (OABF01154) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Dog|Human|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Cytoplasm, Nucleus
  Modification: Phosphorylation (Ser592)
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: WB: 1:100 - 1000
  IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: BAP1
• Gene Full Name: BRCA1 associated protein 1
• Alias Symbols: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase);BRCA1-associated protein 1;cerebral protein 6;cerebral protein-13;HUCEP-13;hucep-6;ubiquitin carboxyl-terminal hydrolase BAP1;UCHL2.
• NCBI Gene Id: 8314
• Protein Name: Ubiquitin carboxyl-terminal hydrolase BAP1
• Description of Target: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
• Uniprot ID: Q92560