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BAG2 Antibody - N-terminal region (OABB01254)

100 ug
$320.00
In Stock
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Gene Symbol:
BAG2
Official Gene Full Name:
BAG family molecular chaperone regulator 2
NCBI Gene Id:
9532
Swissprot Id:
O95816
Alias Symbols:
BAG 2, BAG family molecular chaperone regulator 2, BAG-2, BAG-family molecular chaperone regulator-2, Bag2, BAG2_HUMAN, BCL 2 associated athanogene 2, Bcl-2-associated athanogene 2, BCL2 associated athanogene 2, BCL2-associated athanogene 2, dJ417I1.2(BAG
Replacement Item:
This antibody may replace item sc-101216 from Santa Cruz Biotechnology.
Description of Target:
BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Immunogen affinity purified.
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express BAG2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express BAG2.
Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2(1-14aa MAQAKINAKANEGR), different from the related mouse and rat sequences by two amino acids.
Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution and Storage:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. Store at -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Datasheets/Manuals:
Printable datasheet for anti-BAG2 (OABB01254) antibody
Isotype:
IgG
Application Info:
WB: 0.1-0.5ug/ml

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