Catalog No: OOMC00028
Price: $0.00
SKU
OOMC00028
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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Datasheets/Manuals | Printable datasheet for OOMC00028 |
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Product Format | Lyophilized white solid |
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Additional Information | CAS: 88899-55-2 Molecular Formula: C35H58O9 |
:: | Chemical Name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-oxacyclohexadeca-3,5,11,13-tetraen-2-one |
:: | Primary Activity: Vacuolar H+ ATPase inhibitor, Autophagy modulator |
:: | COVID-19 Rationale: V1-ATPase subunits interact with SARS-CoV-2 Nsp6 and M; Inhibits SARS-CoV-2 in cells |
Reconstitution and Storage | Soluble in DMSO (up to 50 mg/ml, with warming). Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
Purity | > 98% (HPLC); NMR (Conforms) |
Reference | 1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. J.Antibiot. 37 110 / 2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase J.Exp.Biol. 200 1 / 3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells Cell Struct.Func. 23 33 |
Molecular Weight | 622.8 Da |
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- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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