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| Datasheets/Manuals | Printable datasheet for anti-B220 antibody - OAPA00040 |
|---|
| Predicted Species Reactivity | Mouse |
|---|---|
| Clonality | Monoclonal |
| Clone | mB220. |
| Isotype | Rat IgM. |
| Host | Rat |
| Additional Information | Reconstitution: Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4C. |
| :: | Product Type: Rat Anti Mouse Monoclonal. |
| :: | Antibody Properties: Staining antibody. For staining, use 10 ul/106 cells. |
| :: | Product Introduction: B220 (CD45R) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.B220 (CD45R) is required for t-cell activation through the antigen receptor. The first ptpase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. |
| Reconstitution and Storage | Lyophilized: store at 4C. After reconstitution, if not intended for use within a month, aliquot and store at -20C. |
| Immunogen | The immunogen for anti-B220 antibody: purified mouse LN B cells. |
| Purity | Ion exchange column. |
| Gene Symbol | B220 |
|---|---|
| Alias Symbols | RPB1, RPB220, SUA8 |
| NCBI Gene Id | 851415 |
| Description of Target | Rat Anti Mouse B220 (CD45R) |
| Protein Accession # | NP_010141.1 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "B220 Antibody (OAPA00040)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse".
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How long will it take to receive "B220 Antibody (OAPA00040)"?
This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".
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What buffer format is "B220 Antibody (OAPA00040)" provided in?
This item is provided in "".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "B220 Antibody (OAPA00040)"?
This target may also be called "RPB1, RPB220, SUA8" in publications.
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What is the shipping cost for "B220 Antibody (OAPA00040)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "B220 Antibody (OAPA00040)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "B220 Antibody (OAPA00040)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "B220 Antibody (OAPA00040)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "B220"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "B220"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "B220"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "B220"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "B220"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "B220"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.
