AURKC Recombinant Protein (OPCD01554)

Catalog No: OPCD01554

AURKC Recombinant Protein (OPCD01554) using SDS-PAGE

AURKC Recombinant Protein (OPCD01554) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu20-Gln277
  Subcellular Location: Nucleus, Cytoplasm, Chromosome
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: AURKC
• Gene Full Name: aurora kinase C
• Alias Symbols: AIE2;AIK3;ARK3;ARK-3;AurC;aurora 3;aurora kinase C;aurora/IPL1/EG2 protein 2;aurora/IPL1-related kinase 3;aurora-C;aurora-related kinase 3;epididymis secretory protein Li 90;HEL-S-90;serine/threonine kinase 13 (aurora/IPL1-like);serine/threonine-protein kinase 13;serine/threonine-protein kinase aurora-C;SPGF5;STK13.
• NCBI Gene Id: 6795
• Protein Name: Aurora kinase C
• Description of Target: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
• Uniprot ID: Q9UQB9
• Protein Accession #: NP_001015878.1
• Nucleotide Accession #: NM_001015878.1
• Protein Size (# AA): Leu20~Gln277
• Molecular Weight: 34kDa