Catalog No: ARP33364_P050
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ARP33364_P050
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Datasheets/ManualsPrintable datasheet for anti-ATXN7 (ARP33364_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human ATXN7
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 92%; Dog: 92%; Guinea Pig: 85%; Horse: 85%; Human: 100%; Mouse: 85%; Pig: 92%; Rabbit: 92%; Rat: 92%
Peptide SequenceSynthetic peptide located within the following region: TRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTREKELIRHPDSQQPP
Concentration0.5 mg/ml
Blocking PeptideFor anti-ATXN7 (ARP33364_P050) antibody is Catalog # AAP33364 (Previous Catalog # AAPP04410)
ReferenceLin,Y., (2008) Neurosci. Lett. 434 (2), 230-233
Gene SymbolATXN7
Gene Full NameAtaxin 7
Alias SymbolsSCA7, OPCA3, SGF73, ADCAII
NCBI Gene Id6314
Protein NameAtaxin-7
Description of TargetATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Uniprot IDO15265
Protein Accession #NP_000324
Nucleotide Accession #NM_000333
Protein Size (# AA)892
Molecular Weight95kDa
Protein InteractionsVCP; USP22; PICK1; TP53BP2; RAD23A; ATXN7L3; ENY2; PIAS1; SUMO1; UBE2I; SUMO2; KAT2A; AGRN; LRSAM1; ADAM33; CEP70; COG6; TRIM54; CEP72; RNF31; PPP1R12C; CRIM1; TXNDC11; EFEMP2; UBQLN2; CARD10; NOC2L; NUP62; MPRIP; SPRY1; GPRASP1; PNMA1; RABEP1; KALRN; LTB
  1. What is the species homology for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit".

  2. How long will it take to receive "ATXN7 Antibody - middle region (ARP33364_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ATXN7 Antibody - middle region (ARP33364_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    This target may also be called "SCA7, OPCA3, SGF73, ADCAII" in publications.

  5. What is the shipping cost for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "95kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ATXN7 Antibody - middle region (ARP33364_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "ATXN7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ATXN7"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ATXN7"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ATXN7"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ATXN7"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ATXN7"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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