ATP8A2 Antibody - N-terminal region (ARP91821_P050)

Catalog No: ARP91821_P050

Host: Rabbit
Target Name: ATP8A2
Sample Tissue: Mouse Kidney lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Mouse
• Predicted Species Reactivity: Mouse
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of mouse ATP8A2
• Purification: Affinity purified
• Peptide Sequence: Synthetic peptide located within the following region: MSRATSVGDQLEAPARIIYLNQSHLNKFCDNRISTAKYSVLTFLPRFLYE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ATP8A2 (ARP91821_P050) antibody is Catalog # ARP91821_P050

Target Info

• Gene Symbol: ATP8A2
• Gene Full Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
• Alias Symbols: I, a, w, wl, agil, Atpc1b, AI415030
• NCBI Gene Id: 50769
• Protein Name: Phospholipid-transporting ATPase IB
• Description of Target: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
• Uniprot ID: P98200
• Protein Accession #: NP_056618.1
• Nucleotide Accession #: NM_015803.2
• Protein Size (# AA): 1148
• Molecular Weight: 129 kDa