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ATP8A2 Antibody - N-terminal region (ARP91821_P050)

100 ul
$289.00
In Stock
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Tested Species Reactivity:
Mouse
Predicted Species Reactivity:
Mouse
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ATP8A2
Official Gene Full Name:
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
NCBI Gene Id:
50769
Protein Name:
Phospholipid-transporting ATPase IB
Swissprot Id:
P98200
Protein Accession #:
NP_056618.1
Nucleotide Accession #:
NM_015803.2
Alias Symbols:
wl, agil, Atpc1b, AI415030
Description of Target:
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
Protein Size (# AA):
1148
Molecular Weight:
129 kDa
Purification:
Affinity purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ATP8A2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ATP8A2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of mouse ATP8A2
Peptide Sequence:
Synthetic peptide located within the following region: MSRATSVGDQLEAPARIIYLNQSHLNKFCDNRISTAKYSVLTFLPRFLYE
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-ATP8A2 (ARP91821_P050) antibody is Catalog # ARP91821_P050
Datasheets/Manuals:
Printable datasheet for anti-ATP8A2 (ARP91821_P050) antibody

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