ATP6V1B1 Antibody - C-terminal region (OASG07496)

Catalog No: OASG07496

Size:100 uL

Western Blot using HepG2

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
  Function: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
  Cellular Localization: Endomembrane system; Peripheral membrane protein. Note=Endomembrane.
  Tissue Specificity: Expressed in the cochlea and endolymphatic sac.
  Sequence & Domain Family: The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7.
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the C-terminal region of human V-ATPase B1. Location: 350-430aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: V-ATPase B1 Polyclonal Antibody detects endogenous levels of V-ATPase B1 protein.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  ELISA: 1:5000

Target Info

• Gene Symbol: ATP6V1B1
• Gene Full Name: ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
• Alias Symbols: VATB, VMA2, VPP3, DRTA2, RTA1B, ATP6B1
• NCBI Gene Id: 525;
• Description of Target: V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56.8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness.
• Uniprot ID: P15313