ATG7 Recombinant Protein (OPCD01532)

Catalog No: OPCD01532

ATG7 Recombinant Protein (OPCD01532) using SDS-PAGE

ATG7 Recombinant Protein (OPCD01532) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Arg477-Val698
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Atg7
• Gene Full Name: autophagy related 7
• Alias Symbols: 1810013K23Rik;Agp7;Ap;Apg7l;ATG12-activating enzyme E1 ATG7;Atg7l;autophagy-related protein 7;Gm21553;ubiquitin-activating enzyme E1-like protein;ubiquitin-like modifier-activating enzyme ATG7.
• NCBI Gene Id: 74244
• Protein Name: Ubiquitin-like modifier-activating enzyme ATG7
• Description of Target: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
• Uniprot ID: Q9D906
• Protein Accession #: NP_001240646.1
• Nucleotide Accession #: NM_001253717.1
• Protein Size (# AA): Arg477~Val698
• Molecular Weight: 28kDa