Size:100 ul
$320.00
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SKU
OAAB21715
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ATF6 Antibody (OAAB21715)

Catalog#: OAAB21715
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More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Clonality Polyclonal
Host Rabbit
Application WB, IF, IHC-P
Additional Information Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Location: Ubiquitous.
Reconstitution and Storage Store at -20C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4C.
Replacement Item This antibody may replace item sc-14250 from Santa Cruz Biotechnology.
Datasheets/Manuals Printable datasheet for anti-ATF6 (OAAB21715) antibody
Application Info IHC-P 1:100~500
Gene Symbol ATF6
Official Gene Full Name activating transcription factor 6
Alias Symbols ACHM7, ATF6A
NCBI Gene Id 22926
Description of Target This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Swissprot Id P18850
Protein Accession # NP_031374.2
Nucleotide Accession # NM_007348.3
Molecular Weight 75 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ATF6.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ATF6.
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