Size:100 ul
$320.00
Discontinued
SKU
OAAB21715
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ATF6 Antibody (OAAB21715)

Catalog#: OAAB21715
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Predicted Species Reactivity Human, Mouse, Rat
Product Format Liquid. 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Clonality Polyclonal
Host Rabbit
Application WB, IF, IHC-P
Additional Information Function: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Location: Ubiquitous.
Reconstitution and Storage Store at -20C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4C.
Replacement Item This antibody may replace item sc-14250 from Santa Cruz Biotechnology.
Datasheets/Manuals Printable datasheet for anti-ATF6 (OAAB21715) antibody
Application Info IHC-P 1:100~500
Gene Symbol ATF6
Official Gene Full Name activating transcription factor 6
Alias Symbols ACHM7, ATF6A
NCBI Gene Id 22926
Description of Target This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
Swissprot Id P18850
Protein Accession # NP_031374.2
Nucleotide Accession # NM_007348.3
Molecular Weight 75 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ATF6.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ATF6.
  1. What is the species homology for "ATF6 Antibody (OAAB21715)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "ATF6 Antibody (OAAB21715)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "ATF6 Antibody (OAAB21715)" provided in?

    This item is provided in "Liquid. 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ATF6 Antibody (OAAB21715)"?

    This target may also be called "ACHM7, ATF6A" in publications.

  5. What is the shipping cost for "ATF6 Antibody (OAAB21715)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ATF6 Antibody (OAAB21715)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ATF6 Antibody (OAAB21715)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "75 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ATF6 Antibody (OAAB21715)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ATF6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ATF6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ATF6"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ATF6"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ATF6"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ATF6"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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