ATF6 Antibody - N-terminal region (ARP31688_P050)

Catalog No: ARP31688_P050

WB Suggested Anti-ATF6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysateATF6 is supported by BioGPS gene expression data to be expressed in HeLa

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATF6
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 86%; Dog: 79%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Rabbit: 92%; Rat: 79%
• Peptide Sequence: Synthetic peptide located within the following region: GYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKD
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ATF6 (ARP31688_P050) antibody is Catalog # AAP31688 (Previous Catalog # AAPP02475)
• Sample Type Confirmation:

  ATF6 is supported by BioGPS gene expression data to be expressed in HeLa

• Reference: Kerbiriou,M., Biochim. Biophys. Acta 1772 (11-12), 1236-1249 (2007)
• Publications:

  Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. PLoS One. 10, e0115723 (2015). 25695253

  Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. Respir Res. 19, 157 (2018). 30134920

Target Info

• Gene Symbol: ATF6
• Gene Full Name: Activating transcription factor 6
• Alias Symbols: ACHM7, ATF6A
• NCBI Gene Id: 22926
• Protein Name: Cyclic AMP-dependent transcription factor ATF-6 alpha
• Description of Target: ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-171 AB015856.1 2-172 172-265 BC014969.1 124-217 266-336 AB015856.1 267-337 337-650 BC014969.1 289-602 651-1294 AF005887.1 626-1269 1295-2406 AB015856.1 1296-2407 2407-2488 AF005887.1 2375-2456
• Uniprot ID: P18850
• Protein Accession #: NP_031374
• Nucleotide Accession #: NM_007348
• Protein Size (# AA): 670
• Molecular Weight: 74kDa
• Protein Interactions: UBC; MAPK14; FBXO6; ATF6; XBP1; NNMT; DDC; BPGM; TNFRSF1A; APP; SP1; SUMO2; SYVN1; WFS1; SREBF2; YY1; NFYC; CREB1; CREB3L3; GTF2I; ATF6B; SRF; NFYA;