ATF5 Antibody - middle region : HRP (ARP57977_P050-HRP)

Catalog No: ARP57977_P050-HRP

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
• Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: HRP: Horseradish Peroxidase
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATF5
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
• Peptide Sequence: Synthetic peptide located within the following region: LPPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQNKSAALRYRQRK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-ATF5 (ARP57977_P050-HRP) antibody is Catalog # AAP57977 (Previous Catalog # AAPP32388)
• Reference: Zhou,D., (2008) J. Biol. Chem. 283 (11), 7064-7073
• Publications:

  Wei, Y. et al. Cdc34-mediated degradation of ATF5 is blocked by cisplatin. J. Biol. Chem. 283, 18773-81 (2008). WB, Human, Bovine, Pig, Horse, Rat, Guinea pig, Dog, Mouse, Zebrafish 18458088

Target Info

• Gene Symbol: ATF5
• Gene Full Name: Activating transcription factor 5
• Alias Symbols: ATFX, HMFN0395
• NCBI Gene Id: 22809
• Protein Name: Cyclic AMP-dependent transcription factor ATF-5
• Description of Target: ATF5 belongs to the bZIP family. It is transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Loss of ATF5 is associated with hepatocellular carcinoma.
• Uniprot ID: B3KND3
• Protein Accession #: NP_036200
• Nucleotide Accession #: NM_012068
• Protein Size (# AA): 282
• Molecular Weight: 31kDa
• Protein Interactions: CEBPE; CEBPA; GIT2; ATXN1; EP300; CCND3; GABBR2; DISC1; GABBR1; CEBPG; CDC34; TRIB3; UBC; CD34;